phosphotungstic acidcatalyzed strecker three-component reaction of amino acids, aldehydes, and trimethylsilyl cyanide
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abstract
a simple and efficient one-pot, three-component strecker reaction of protected amino acids, aromatic aldehydes, and trimethylsilyl cyanide has been developed for the synthesis of chiral α-amino nitriles. the reaction was carried out in the presence of catalytic amount of phosphotungstic acid (h3[p(w3o10)4]) as an environmentally friendly catalyst.
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Journal title:
organic chemistry researchPublisher: iranian chemical society
ISSN
volume 1
issue 1 2015
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